The Practitioner\u27s Corner: An exploration of municipal active living charter development and advocacy

Background: Numerous municipal active living-­‐related charters have been adopted to promote physical activity in Canada throughout the past decade. Despite this trend, there are few published critical examinations of the process through which charters are developed and used. Purpose: Thus, the purpose of this study was to establish greater understanding of active living charter development and advocacy. Methods: Semi-­‐structured interviews were conducted with eight primary contributors to different active living-­‐related charters across Ontario, Canada. Interview questions explored participants’ experiences developing and advocating for an active living charter. Interviews were analyzed using open, axial, and selective coding. Results and Conclusions: Participants consistently described a process whereby an impetus triggered the development of a charter, which was subsequently adopted by regional or municipal council. Continued advocacy to develop awareness of the charter and to promote desired outcomes in the community was valued and the capacity of the working group as well as the local political context played pivotal roles in determining how the charter was implemented. Outcomes were, however, only objectively evaluated in one case that was described – evaluation being a process that many participants thought was omitted in regard to their own charter. This work provides practical guidance for health professionals developing regional active living charters as a component of broader advocacy efforts

The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

We are grateful to the animal house staff for looking after the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (grants BB/G009953/1 and BB/J020028/1) to JRS and SEM. DD was supported by a studentship from the Centre for Genome Enabled Biology and Medicine, Aberdeen, UK, and CG was supported by a BBSRC EastBio studentship. Joint meetings were funded by a BBSRC China partnering award (BB/JO20028/1).Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

GRANT SUPPORT This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer reviewedPublisher PD

Nucleotide Frequencies in Human Genome and Fibonacci Numbers

This work presents a mathematical model that establishes an interesting connection between nucleotide frequencies in human single-stranded DNA and the famous Fibonacci's numbers. The model relies on two assumptions. First, Chargaff's second parity rule should be valid, and, second, the nucleotide frequencies should approach limit values when the number of bases is sufficiently large. Under these two hypotheses, it is possible to predict the human nucleotide frequencies with accuracy. It is noteworthy, that the predicted values are solutions of an optimization problem, which is commonplace in many nature's phenomena.Comment: 12 pages, 2 figure

Person-environment fit and retention of racially minoritized college students: Recommendations for faculty, support staff, and administrators

Although colleges in the United States have become increasingly racially and ethnically diverse, degree attainment remains disproportionately low among students from underrepresented and minoritized racial backgrounds. In this paper, we discuss the interactive influence of both person and environment factors in shaping academic persistence and argue that college administrators, faculty, and student support staff can intervene and take specific steps to improve the academic experience of racially minoritized college students. To this end, we offer specific evidence-based recommendations for campus leaders and stakeholders on how to adapt their campus community to facilitate the requisite person-environment fit to maximize academic persistence

Unique Microbial Communities Persist in Individual Cystic Fibrosis Patients throughout a Clinical Exacerbation

Cystic fibrosis (CF) is caused by inherited mutations in the cystic fibrosis transmembrane conductance regulator gene and results in a lung environment that is highly conducive to polymicrobial infection. Over a lifetime, decreasing bacterial diversity and the presence of Pseudomonas aeruginosa in the lung are correlated with worsening lung disease. However, to date, no change in community diversity, overall microbial load or individual microbes has been shown to correlate with the onset of an acute exacerbation in CF patients. We followed 17 adult CF patients throughout the course of clinical exacerbation, treatment and recovery, using deep sequencing and quantitative PCR to characterize spontaneously expectorated sputum sample

The effects of graded levels of calorie restriction : I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

We acknowledge the BSU staff for their invaluable help with caring for the animals and anonymous referees for their inputs. The work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK (Standard grant BB/G009953/1 and China partnering award BB/JO20028/1). The authors declare no competing interests.Peer reviewedPublisher PD